Melatonin


BACKGROUND

Melatonin is a hormone secreted by the pineal gland in the brain but also in mammalian bone marrow, platelets, gastrointestinal tract, eyes, skin, and lymphocytes. [1] It helps regulate other hormones and maintains the body's circadian rhythm. The circadian rhythm is an internal 24-hour master clock that plays a critical role in when we fall asleep and wake up. It plays a vitally important role in regulating the body’s daily and annual biological rhythms and thus the sleep/wake cycle. Research suggests that melatonin supports antioxidant activity, cardiovascular health, and immune function as well. [2-4]

BENEFITS

  • Supports the Natural Function of the Pineal Gland
  • Helps Support Healthy Sleep Patterns
  • May Support Antioxidant Activity and Cardiovascular Health
  • May Support Immune System Activity

 

HOW MELATONIN WORKS IN OUR BODY AND PRODUCES THE DESIRED EFFECTS?

Studies have shown that melatonin supports the quality of healthy sleep as it relates to falling asleep, sleep efficiency (percent of time asleep to total time in bed), and awakening.

Melatonin has also been closely studied for its role in supporting antioxidant activity, especially since intracellular melatonin is concentrated in the mitochondria, a major site of oxidative metabolism. Melatonin has been found to support extracellular antioxidant activity, support glutathione production, and stimulate production of intracellular antioxidant enzymes—including superoxide dismutases and glutathione peroxidase. [3]

HOW MUCH SHOULD I TAKE? IS IT SAFE?

Melatonin has a very low side effects profile. Some people may have vivid dreams or nightmares when they take melatonin. Taking too much melatonin may also disrupt circadian rhythms. Melatonin can cause drowsiness if taken during the day. Additional side effects include stomach cramps, dizziness, headache, irritability, decreased libido, breast enlargement in men (called gynecomastia), and reduced sperm count. Do not drive or operate heavy machinery 5-6 hours after taking melatonin. Daily doses between 0.5 mg to 5 mg taken at bedtime have proven to be the recommended intake. We include 2mg of melatonin in our nootropic stack which is to be taken when seeking maximum relaxation and a complete rejuvenation (no more than once per day).

MELATONIN IS AVAILABLE IN OUR SLEEP NOOTROPIC WHICH IS SOLD BOTH INDIVIDUALLY AND AT A DISCOUNT WHEN PURCHASED AS PART OF OUR FULL STACK.

Questions? Feel free to email us with any questions you may have about melatonin or any other ingredients in our products!

 

RESEARCH

  1. Srinivasan V, Pandi-Perumal SR, Brzezinski A, et al. Melatonin, immune function and cancer. Recent Pat Endocr Metab Immune Drug Discov. 2011 May;5(2):109-23.
  2. Korkmaz A, Reiter RJ, Topal T, et al. Melatonin: an established antioxidant worthy of use in clinical trials. Mol Med. 2009 Jan-Feb;15(1-2):43-50. Review.
  3. Dominguez-Rodriguez A, Abreu-Gonzalez P, Reiter RJ. Melatonin and Cardiovascular Disease: Myth or Reality? [in Spanish]. Rev Esp Cardiol. 2012 Mar;65(3):215-218. Epub 2012 Jan 13.
  4. Maestroni GJ. The immunotherapeutic potential of melatonin. Expert Opin Investig Drugs. 2001 Mar;10(3):467-76. Review.