Vinpocetine


BACKGROUND

Vinpocetine is a synthetic alkaloid derived from the seeds of the periwinkle plant, a flowering plant native to Europe, northwest Africa and southwest Asia. Vinpocetine is often used as a nootropic compound to promote memory enhancement, and has a history of usage in European countries to treat cognitive decline, stroke recovery, and improve cerebral circulation among other human functions. Vinpocetine’s roles in supporting brain function include its influence on cerebral circulation, its support of antioxidant activity in the brain, and its role in supporting neuronal health. [4-6] This mix of cerebral support has the ability to enhance overall brain tissue health and function.

BENEFITS

  • Supports Healthy Brain Function
  • Supports Brain Antioxidant Activity
  • Supports Blood Flow to the Brain
  • Supports Oxygenation of Brain Tissue

HOW VINPOCETINE WORKS IN OUR BODY AND PRODUCES THE DESIRED EFFECTS?

Vinpocetine is a powerful tension reliever and memory enhancer. This is achieved by reducing tension in blood vessels by acting directly on the structure of blood vessels themselves or by inhibiting the sodium and/or calcium electrical charges that promote tension. By causing mild dilation of blood vessels, the increased cerebral blood flow and reduction of the core inflammatory gene signal (NF-kappaB) in blood vessels is able to relieve tension. Vinpocetine demonstrates antioxidant protection as well. It boosts neurotransmitters involved with cerebral enhancement and memory, such as dopamine, nor-adrenaline, and acetylcholine. By enhancing glucose uptake in brain cells leading to energy production, vinpocetine will facilitate cerebral metabolism and improve blood flow in the brain.

The fascinating attribute of Vinpocetine is that it enhances the brain’s ability to process information faster while simultaneously helping the brain’s vascular system relax and flow better. By enhancing circulation to your brain, your brain will be better oxygenated and nourished – including enhanced transport of the other nutrients you take to your brain consequently improving cerebral functions including memory. [3]

In one study, researchers tested the working memory of 24 healthy volunteers. The study found that Ginkgo biloba (40 mg) and vinpocetine (10 mg) taken together significantly decreased reaction times for a working memory task after the combination was consumed for 14 days. The accumulation of vinpocetine in motor portions of the brain suggests that this reaction time increases may be a result of enhanced motor function. [2]

In another study, 12 healthy female volunteers received pre-treatments with vinpocetine 10, 20, 40 mg and placebo for two days. On the third day of treatment subjects completed a battery of psychological tests including Ciritcal Flicker Fusion (CFF), Choice Reaction Time (CRT), Subjective Ratings of Drug Effects (LARS) and a Sternberg Memory Scanning Test. No statistically significant changes from placebo were observed on CFF, CRT or subjective ratings of drug effects. However, memory as assessed using the Sternberg technique was found to be significantly improved following treatment with vinpocetine 40 mg when compared to placebo and results suggested a localized effect of the drug. [1]

HOW MUCH SHOULD I TAKE? IS IT SAFE?

Various studies have shown positive benefits from vinpocetine at amounts between 10 to 30 mg/day, and some at 40 mg/day. Many studies done with vinpocetine show the dose-response curve leveling off or declining above 40 mg/day or more. In all the studies completed between 10 and 40 mg/day, there was no toxicity or adverse side-effects recorded. We include 20mg of vinpocetine in our nootropic stack which is to be taken when extreme focus and cognitive enhancement is needed (no more than once per day).

VINPOCETINE IS AVAILABLE IN OUR BOOSTER NOOTROPIC WHICH IS SOLD BOTH INDIVIDUALLY AND AT A DISCOUNT WHEN PURCHASED AS PART OF OUR FULL STACK.

Questions? Feel free to email us with any questions you may have about vinpocetine or any other ingredients in our products!

 

RESEARCH

  1. Subhan, Z. & Hindmarch, I. Eur J Clin Pharmacol (1985) 28: 567. doi:10.1007/BF00544068
  2. Polich, J. and Gloria, R. (2001), Cognitive effects of a Ginkgo biloba/vinpocetine compound in normal adults: systematic assessment of perception, attention and memory. Hum. Psychopharmacol. Clin. Exp., 16: 409–416. doi: 10.1002/hup.308
  3. Ogunrin A. Effect of Vinpocetine (CognitolTM) on Cognitive Performances of a Nigerian Population. Annals of Medical and Health Sciences Research. 2014;4(4):654-661. doi:10.4103/2141-9248.139368.
  4. Hadjiev D. Asymptomatic ischemic cerebrovascular disorders and neuroprotection with vinpocetine. Ideggyogy Sz. 2003 May;56(5-6):166-72. [PMID: 12861957]
  5. Muravyov AV, Yakusevich VV, Chuchkanov FA, et al. Hemorheological efficiency of drugs, targeting on intracellular phosphodiesterase activity: in vitro study. Clin Hemorheol Microcirc. 2007;36(4):327-34. [PMID: 17502703]
  6. Vinpocetine. Monograph. Altern Med Rev. 2002 Jun;7(3):240-43. [PMID: 12126465]