Vitamins B6 (as pyridoxal 5’-phosphate), B12 (as methylcobalamin), and folate (as 5-MTHF) are essential homocysteine remethylation cofactors; as such, they support the maintenance of healthy homocysteine levels. Normal blood levels of homocysteine are are associated with healthy cognition in the elderly and healthy cerebrovascular function.
The brain may be protected by improving methylation by providing the nutritional cofactors needed for proper functioning of the methionine cycle. 5-MTHF (5-methyltetrahydrofolate) may better support folate nutrition in those with digestive issues and those with genetic variations in folic acid metabolism. The form of 5-MTHF in Crush is Quatrefolic, which is proven to have greater stability, solubility, and bioavailability over calcium salt forms of 5-MTHF.
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