Vitamins B6 and B12


Vitamins B6 (as pyridoxal 5’-phosphate), B12 (as methylcobalamin), and folate (as 5-MTHF) are essential homocysteine remethylation cofactors; as such, they support the maintenance of healthy homocysteine levels. Normal blood levels of homocysteine are are associated with healthy cognition in the elderly and healthy cerebrovascular function.[1]

The brain may be protected by improving methylation by providing the nutritional cofactors needed for proper functioning of the methionine cycle.[2] 5-MTHF (5-methyltetrahydrofolate) may better support folate nutrition in those with digestive issues and those with genetic variations in folic acid metabolism. The form of 5-MTHF in Crush is Quatrefolic, which is proven to have greater stability, solubility, and bioavailability over calcium salt forms of 5-MTHF.

 

1. Malouf R, Grimley Evans J. The effect of vitamin B6 on cognition. Cochrane Database Syst Rev. 2003;(4):CD004393. [PMID: 14584010]

2. Miller AL. The methionine-homocysteine cycle and its effects on cognitive diseases. Altern Med Rev. 2003 Feb;8(1):7-19. [PMID: 12611557]